So, last week we opened the Tuesday Feature and it went down brilliantly! It’s already the second most viewed post we’ve ever had on the blog. Thank you all for reading and we’re really glad you enjoyed it.

Matt in New YorkThis week we cross the pond to New York to catch up with Faculty Alumnus Matt Paul. Matt studied BSc Genetics with Industrial Experience here at the Faculty, graduating in 2012, and he tells us below just how inspiring he found some our staff.

He is now a 3rd year PhD student in the Department of Biology, New York University, in the labs of Dr. Andreas Hochwagen and Dr. Sevinc Ercan. It’s been an exciting journey for Matt, and you can find out more about it below.

Hi Matt. Thanks for talking to us. Can you please explain your research, for the layman, in ten sentences or less?

I study the three-dimensional organization of the genome. DNA is not just randomly packaged into the nucleus, like a bowl of spaghetti. Regions of the DNA tend to be found in specific places, next to other regions. Where a loci is positioned can have an impact on various processes including transcription and DNA repair.

I use yeast and worms to study how genome organization regulates cell division to produce sex cells (meiosis) and the balancing of expression of X-chromosome genes between sexes (dosage compensation).

How could your research benefit the people reading this blog?

The study of chromosome structure and how it alters genome function is very basic and can have a wide varietyMatt in the lab of impacts.

The most direct example for the translation of my work to the real world would be in meiosis. During this cell division you produce the sex cells. The three-dimensional structure of the genome is important in ensuring that there is correct segregation of chromosomes into these cells. Errors could result in infertility, miscarriage, or disorders such as downs syndrome.

Can we ask how you first got interested in your research area?

Growing up was a very exciting time to be a budding biologist. Genomes were being sequenced and the promise that these projects brought was exciting. Though this was a huge step, there now seems to be even more questions about how the genome works.

The study of chromatin was definitely one of the hot topics in biology when I arrived at University of Manchester. Specifically, what I found fascinating was how so called ‘junk DNA’ actually coded for important information.

I got a chance at Manchester to investigate this topic by looking at non-coding RNAs with Dr. Matthew Ronshaugen in my final year. Many of these help organize genome structure, so it was a small leap from my work there to what I do now.

Do you have any science heroes? Who inspired you?

There been a steady stream of inspiring people without whom I wouldn’t have got so deep into science.

I have been fortunate to have many good science teachers, lecturers, and mentors along the way. Now, just being around my colleagues, the many hard-working biologists who are so passionate about their work, provides a lot of inspiration.

One person who I haven’t had contact with directly but admire is Craig Venter. Though I don’t necessarily agree with some of the moral aspects of his work, his insight and force of will played key roles in the genomic revolution. Furthermore, his current work in synthetic biology continues to be really exciting.

Could you tell us a bit about your interests outside of science?

Matt with crazy eyesLiving in New York certainly allows you to explore many interests. It’s a big city with a big cultural output, so I like to try and do as many new things as possible.

My favorite activity is going to gigs, and as good as it is here, I do occasionally miss the Manchester music scene.

Beyond this, I am also captain of NYU squash team so that keeps me busy and healthy.

And that wraps up the second Thursday Feature from the Faculty of Life Sciences’ blog. If anyone’s wishing they were in New York, or fit enough to be the captain of a squash team, have a look outside. At least it’s sunny today.

Our thanks go to Matt Paul – it’s great to see an ex-student thriving! It’s Brain Awareness Week next week, so we’ll be here with Dr. Jack Rivers-Auty. Thanks for reading and please come back next Tuesday!

 

Interview by Fran Slater, Images courtesy of Matt Paul

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